[Preparation of kangfuxin colon targeting micro-pellets].

Objective: To prepare coated micro-pellets of pH-dependent and enzyme-dependent Kangfuxin colon targeting delivery system,to make them go to colon,then release,educe partial effect.Method: We eploy pan-pill to prepare simple pellets,and prepare tunicatus pellets with fluidzed bed coating.We investigated the preparation and parameter of pellets,so,we bolting the best shaping and tunicatus artwork.Result: The ingredients for preparing the micro-pellets are 125% starch +2% CMC-Na,and add 30% ethanol to be binder,pellets were coated with Eudragit S100 to prepare ph-dependent and pectin-HPMC to prepare enzyme-dependent colon targeting micro-pellets.Conclusion: We get two micro-pellets of pH-dependent and enzyme-dependent Kangfuxin colon targeting.