Bilateral Renal Infarctions During the Use of Sumatriptan

Triptans are effective as acute abortive therapy for migraine and cluster headaches by targeting the serotonin 5-HT1B/1D receptors located in the cerebral, coronary, and peripheral arteries. This class of medications inhibits the release of vasoactive peptides and promotes vasoconstriction, combating the pathologic vasodilatation contributing to migraine headaches.1 Potential complications of these vasoconstrictive properties include myocardial infarction,2, 3 cerebrovascular accident,4 ischemic colitis,5 and spinal cord infarction.6 We present a case of bilateral renal infarctions associated with sumatriptan use.