Abstract 104: Racial and ethnic differences in genomic profiling of early onset colorectal cancer

Introduction: Incidence and mortality of early onset colorectal cancer (EOCRC), defined as CRC diagnosed prior to 50, are rising, with some studies showing distinct race/ethnic trends. Although reasons are likely multifactorial, genomic differences may play a role. We examined tumor genomic profiles across race/ethnicity in a diverse cohort of EOCRC patients. Procedures: Next generation sequencing data from Memorial Sloan Kettering Cancer Center (MSK341, MSK410, MSK468) and Dana-Farber Cancer Institute (DFCI1, DFCI2, DFCI3) was pulled from AACR Project GENIE (v8.1). Due to limited racial/ethnic diversity, we added our institutional (UT Southwestern) EOCRC data given enrichment in Hispanic patients. Patients were divided into 4 racial/ethnic groups: White-Hispanic, White Non-Hispanic, Asian, Black. Using the Fisher Exact test (p Citation Format: David M. Hein, Weiye Deng, Syed A. Kazmi, Amy L. Jones, Radhika Kainthla, Brandi Cantarel, Nina N. Sanford. Racial and ethnic differences in genomic profiling of early onset colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 104.