Combination of Amino‐Terminal Pro‐BNP, Estimated GFR, and High‐Sensitivity CRP for Predicting Cardiorenal Syndrome Type 1 in Acute Myocardial Infarction Patients

Background Cardiorenal syndrome type 1 (CRS1) as a complication of acute myocardial infarction can lead to adverse outcomes, and a method for early detection is needed. This study investigated the individual and integrated effectiveness of amino‐terminal pro–brain natriuretic peptide (Pro‐BNP), estimated glomerular filtration rate (eGFR), and high‐sensitivity C‐reactive protein (CRP) as predictive factors for CRS1 in patients with acute myocardial infarction. Methods and Results In a retrospective analysis of 2094 patients with acute myocardial infarction, risk factors for CRS1 were analyzed by logistic regression. Receiver operating characteristic curves were constructed to determine the predictive ability of the biomarkers individually and in combination. Overall, 177 patients (8.45%) developed CRS1 during hospitalization. On multivariable analysis, all 3 biomarkers were independent predictors of CRS1 with odds radios and 95% confidence intervals for a 1‐SD change of 1.792 (1.311‐2.450) for log(amino‐te...