Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

Frances Wensley,Pei Gao,Stephen Burgess,Stephen Kaptoge,Emanuele Di Angelantonio,Tina Shah,James C. Engert,Robert Clarke,George Davey Smith,Børge G. Nordestgaard,Danish Saleheen,Nilesh J. Samani,Manjinder S. Sandhu,S. Anand,Mark B. Pepys,Liam Smeeth,John C. Whittaker,Juan P. Casas,Simon G. Thompson,Aroon D. Hingorani,John Danesh,Guony Eiriksdottir,T. B. Harris,L. J. Launer,V. Gudnason,Aaron R. Folsom,Gavin Andrews,Christie M. Ballantyne,N.J. Samani,Alistair S. Hall,Peter S. Braund,Anthony J. Balmforth,P. H. Whincup,Richard Morris,Debbie A. Lawlor,Gordon Lowe,Nicholas J. Timpson,Shanil Ebrahim,Y Ben-Shlomo,G Davey Smith,B. G. Nordestgaard,A. Tybjærg-Hansen,Jeppe Zacho,Mark T. Brown,Manj S. Sandhu,Sally L. Ricketts,Sofie Ashford,Leslie A. Lange,Alex P. Reiner,Mary Cushman,Russell P. Tracy,C. Wu,J Ge,Y. Zou,A. Sun,Joseph Hung,Brendan M. McQuillan,P. Thompson,John Beilby,Nicole M. Warrington,Lyle J. Palmer,Christoph Wanner,Christiane Drechsler,Michael M. Hoffmann,F. G. R. Fowkes,Ioanna Tzoulaki,Meena Kumari,Michelle A. Miller,Michael Marmot,Charlotte N. Onland-Moret,Y. T. van der Schouw,J. M. A. Boer,Cisca Wijmenga,K. T. Khaw,R. S. Vasan,Renate B. Schnabel,J. F. Yamamoto,Emelia J. Benjamin,Heribert Schunkert,Jeanette Erdmann,Inke R. Koenig,Christian Hengstenberg,Benedetta D. Chiodini,M.G. Franzosi,Silvia Pietri,Francesca Gori,Megan E. Rudock,Yongmei Liu,Kurt Lohman,S.E. Humphries,Anders Hamsten,Paul Norman,Graeme J. Hankey,Konrad Jamrozik,Eric B. Rimm,J. K. Pai,Bruce M. Psaty,Susan R. Heckbert,J. C. Bis,Salim Yusuf,S. Anand,Jc Engert,C. Xie,Rory Collins,Rachel Clarke,D H Bennett,J.S. Kooner,Jenny Chambers,Paul Elliott,Winfried Maerz,Marcus E. Kleber,Bernhard O. Boehm,Bernhard R. Winkelmann,Olle Melander,Göran Berglund,Wolfgang Koenig,Barbara Thorand,Jens Baumert,A Peters,JoAnn E. Manson,J.A. Cooper,P.J. Talmud,Per Ladenvall,Lovisa E. Johansson,Jan-Håkan Jansson,Göran Hallmans,Muredach P. Reilly,Liming Qu,Mingyao Li,Daniel J. Rader,Hugh Watkins,Jemma C. Hopewell,D. Saleheen,J. Danesh,Philippe Frossard,Naveed Sattar,Michele Robertson,J. Shepherd,Ernst J. Schaefer,A. Hofman,J. C. M. Witteman,Isabella Kardys,Abbas Dehghan,U. de Faire,Anna M. Bennet,Bruna Gigante,Karin Leander,Bas J.M. Peters,A. H. Maitland-van der Zee,A. de Boer,Olaf H. Klungel,Philip Greenland,J. Dai,S. Liu,Eric J. Brunner,Mika Kivimäki,D. O'Reilly,Ian Ford,Chris J. Packard

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

2011

Frances Wensley
Pei Gao
Stephen Burgess
Stephen Kaptoge
Emanuele Di Angelantonio
Tina Shah
James C. Engert
Robert Clarke
George Davey Smith
Børge G. Nordestgaard
Danish Saleheen
Nilesh J. Samani
Manjinder S. Sandhu
S. Anand
Mark B. Pepys
Liam Smeeth
John C. Whittaker
Juan P. Casas
Simon G. Thompson
Aroon D. Hingorani
John Danesh
Guony Eiriksdottir
T. B. Harris
L. J. Launer
V. Gudnason
Aaron R. Folsom
Gavin Andrews
Christie M. Ballantyne
N.J. Samani
Alistair S. Hall
Peter S. Braund
Anthony J. Balmforth
P. H. Whincup
Richard Morris
Debbie A. Lawlor
Gordon Lowe
Nicholas J. Timpson
Shanil Ebrahim
Y Ben-Shlomo
G Davey Smith
B. G. Nordestgaard
A. Tybjærg-Hansen
Jeppe Zacho
Mark T. Brown
Manj S. Sandhu
Sally L. Ricketts
Sofie Ashford
Leslie A. Lange
Alex P. Reiner
Mary Cushman
Russell P. Tracy
C. Wu
J Ge
Y. Zou
A. Sun
Joseph Hung
Brendan M. McQuillan
P. Thompson
John Beilby
Nicole M. Warrington
Lyle J. Palmer
Christoph Wanner
Christiane Drechsler
Michael M. Hoffmann
F. G. R. Fowkes
Ioanna Tzoulaki
Meena Kumari
Michelle A. Miller
Michael Marmot
Charlotte N. Onland-Moret
Y. T. van der Schouw
J. M. A. Boer
Cisca Wijmenga
K. T. Khaw
R. S. Vasan
Renate B. Schnabel
J. F. Yamamoto
Emelia J. Benjamin
Heribert Schunkert
Jeanette Erdmann
Inke R. Koenig
Christian Hengstenberg
Benedetta D. Chiodini
M.G. Franzosi
Silvia Pietri
Francesca Gori
Megan E. Rudock
Yongmei Liu
Kurt Lohman
S.E. Humphries
Anders Hamsten
Paul Norman
Graeme J. Hankey
Konrad Jamrozik
Eric B. Rimm
J. K. Pai
Bruce M. Psaty
Susan R. Heckbert
J. C. Bis
Salim Yusuf
S. Anand
Jc Engert
C. Xie
Rory Collins
Rachel Clarke
D H Bennett
J.S. Kooner
Jenny Chambers
Paul Elliott
Winfried Maerz
Marcus E. Kleber
Bernhard O. Boehm
Bernhard R. Winkelmann
Olle Melander
Göran Berglund
Wolfgang Koenig
Barbara Thorand
Jens Baumert
A Peters
JoAnn E. Manson
J.A. Cooper
P.J. Talmud
Per Ladenvall
Lovisa E. Johansson
Jan-Håkan Jansson
Göran Hallmans
Muredach P. Reilly
Liming Qu
Mingyao Li
Daniel J. Rader
Hugh Watkins
Jemma C. Hopewell
D. Saleheen
J. Danesh
Philippe Frossard
Naveed Sattar
Michele Robertson
J. Shepherd
Ernst J. Schaefer
A. Hofman
J. C. M. Witteman
Isabella Kardys
Abbas Dehghan
U. de Faire
Anna M. Bennet
Bruna Gigante
Karin Leander
Bas J.M. Peters
A. H. Maitland-van der Zee
A. de Boer
Olaf H. Klungel
Philip Greenland
J. Dai
S. Liu
Eric J. Brunner
Mika Kivimäki
D. O'Reilly
Ian Ford
Chris J. Packard

Objective To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease. Design Mendelian randomisation meta-analysis of ind ...

Keywords:

Prospective cohort study
Mendelian Randomization Analysis
Heart disease
Pathology
Myocardial infarction
Allele frequency
C-reactive protein
Mendelian inheritance
Gene
Medicine
Individual participant data
coronary heart disease

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