GRK2-Mediated Desensitization of AdipoR1 in Failing Heart
2015
Background
Phosphorylative desensitization of G-protein coupled receptors (GPCR) contributes significantly to post-myocardial infarction (MI) remodeling and heart failure (HF). Here, we determined whether adiponectin receptors 1 and 2 (AdipoR1/AdipoR2, the 7-transmembrane domain-containing receptors mediating adiponectin functions) are phosphorylatively modified and functionally impaired post-MI.
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