Interstital lung disease rates and risk factors in a UK lung cancer screening trial

Introduction: Target populations for lung cancer screening by Low-Dose CT (LDCT) share common risk factors for some Interstitial Lung Diseases (ILDs) including Idiopathic Pulmonary Fibrosis (IPF) such as smoking history and advancing age. Here we report ILD cases identified within the Lung Screen Uptake Trial, a UK based dual centre LDCT lung cancer screening demonstration pilot in a population with high levels of socioeconomic deprivation. Methods: High-risk patients aged 60 to 75 were invited to a ‘lung health check appointment’. Those attending were offered a LDCT if they met the required threshold of lung cancer risk. Scans were reported by thoracic radiologists. ILD findings were classified as IPF-like or non-IPF like, as well as rated according to severity. We performed univariate analysis to determine the relationship of known ILD-risk factors and prevalence of ILD-like findings. Results: 770 individuals underwent a baseline screening LDCT. 54 (6.9%) showed features of ILD (Tab 1). Male gender was the only significantly associated predictor for the presence of radiological ILD (Tab 2). Conclusion: Prevalence of IPF like pattern in this cohort with high lung cancer risk is increased compared to published aged-matched population data (