Effect of Cisplatin on Glomerular Filltration Rate and Effective Renal Plasma Flow

While cisplatin has been widely used in the treatment of a variety of cancers, nephrotoxicity is one of the major problems which frequently limit clinical usefulness of cisplatin. This study has been conducted to investigate nephrotoxicity of cisplatin in terms of changes in glomerular filtration rate (GFR) and effective renal plasma flow (EFPF) measured by the simultaneous use of and , before and after administration of cisplatin, in 12 patients with lung cancer and four patients with esophageal cancer. Cisplatin was administrated at total doses of with two hour hydration and diuresis method. GFR determined by the use of had a good correlation with 24-hour creatinine clearance rate (r=0.77, p and was a useful tool for the measurement of GFR and ERPF respectively.