The effect of the antioxidant drug "U-74389G" on amylase during ischemia reperfusion injury in rats

Background: This experimental study examined the effect of the antioxidant drug U-74389G on a rat model and particularly in an ischemia-reperfusion protocol. Settings and Design: The beneficial effect or noneffectiveness of that molecule was studied biochemically using blood mean amylase (A) levels. Materials and Methods: Forty rats of mean weight 231.875 g were used in the study. The levels were measured at 60 min of reperfusion (Groups A and C) and at 120 min of reperfusion (Groups B and D) with the administration of the drug U-74389G in Groups C and D. Results: U-74389G administration significantly decreased the predicted A levels by 8.40 ± 2.02% ( P = 0.0001). Reperfusion time kept nonsignificantly increased the predicted A levels by 1.68 ± 2.44% ( P = 0.4103). However, U-74389G administration and reperfusion time together produced a significant combined effect in keeping decreased the predicted A levels by 4.67 ± 1.26% ( P = 0.0005). Conclusions: U-74389G administration whether it interacted or not with reperfusion time has a significant decreasing beneficial restoring short-term effect on amylase levels.