Comparison of Incidence and Outcomes of Cardiogenic Shock Complicating Posterior (Inferior) Versus Anterior ST-Elevation Myocardial Infarction

Abstract Cardiogenic shock (CS) is a catastrophic consequence of ST-elevation myocardial infarction (STEMI). CS has been reported to be associated less often with inferior wall (IWMI) than anterior wall STEMI (AWMI). We queried the National Inpatient Sample databases from January 2010 to September 2015 to identify all patients aged ≥18 years admitted with AWMI or IWMI. Patients with a concomitant diagnosis of CS were then identified. Complex samples multivariable logistic regression models were used to compare the incidence, management, and in-hospital mortality of CS complicating IWMI vs. AWMI. The incidence of CS was lower in IWMI (9.5%) vs. AWMI (14.1%), adjusted OR [aOR], 0.84 [95% CI, 0.81-0.87]. Revascularization rates with either PCI or CABG were similar in CS complicating IWMI vs. AWMI (80.9% vs. 80.3%; aOR, 1.05; 95% CI, 0.97-1.14). The reported use of percutaneous mechanical circulatory support devices was lower in patients with CS-IWMI vs. CS-AWMI (44.7% vs. 61.0%; aOR, 0.55; 95% CI, 0.52-0.59). In-hospital mortality was modestly lower in patients with CS complicating IWMI vs. AWMI (30.3% vs. 31.9%; aOR, 0.80; 95% CI, 0.75-0.86). Use of percutaneous mechanical circulatory support was not associated with lower in-hospital mortality in either CS-AWMI (30.0% vs. 34.7; aOR, 1.04; 95% CI, 0.94-1.14) or CS-IWMI (31.0% vs. 29.8%; aOR, 1.20; 95% CI, 1.08-1.33). In conclusion, the incidence of CS in the contemporary era is lower in patients with IWMI compared with those with AWMI. CS complicating STEMI is associated with higher in-hospital mortality in AWMI vs. IWMI, and outcomes were not different with or without percutaneous circulatory support.