Diagnosing Insulin Resistance by Simple Quantitative Methods in Subjects With Normal Glucose Metabolism Response to Karne, Chen, and Quon

We thank Karne et al. for their comments (1) on our article (2). The ideal method to evaluate insulin resistance and insulin sensitivity, outside of the euglycemic-hyperinsulinemic clamp, has not yet been fully established. However, the minimal model, extensively used during the past decades, is considered a valuable surrogate of the clamp (3–5). The genetic factors involved in insulin sensitivity are better determined with the minimal model approach than with indirect methods based …