Salivary Gland Hyalinizing Clear Cell Carcinoma.

Hyalinizing clear cell carcinoma (HCCC) is a rare malignant salivary gland tumor that was characterized as a distinct entity by Milchgrub et al. in 1994 [1]. It has a slight female predominance with ages ranging from 25 to 87 years (mean, 59.4 years) [2]. Most cases occur in the oral cavity, mainly the palate and tongue [2]. Histologically, HCCC is characterized by the predominance of clear cells embedded in a characteristic dual hyaline and fibrocellular stroma [3]. In 2011, Antonescu et al. [2] identified EWSR1 rearrangements in this tumor, which have been subsequently observed in 82% of cases. This genetic change allows the distinction of HCCC from other salivary gland neoplasms with a clear cell phenotype. Here, we present a typical case of HCCC, which we believe is the first case report from Taiwan.