[Coagulative and fibrinolytic changes in patients with essential hypertension and the effect of sustained-release nifedipine].

Objective To investigatethechangesof coagulationandfibrinolysisstatusinpatientswithessentialhypertension(EH)andobservethetherapeuticeffectof sustained-releasenifedipine.Methods Ninety-nineEH patientsweredivided accordingto theirdiastolicbloodpressure (DBP)intomildgroup(48cases),moderategroup(29cases)andseveregroup(22cases),and25patientsamongthegroupswerechosenat randomto receive sustained-releasenifedipinefor2weeks.Twenty healthysubjectsservedas controlgroup.PlasmaD-dimer(DD),fibrinmonomer(FM)andtissue-typeplasminogenactivitor(tPA)levelsweredeterminedin allthesubjectsby enzyme-linkedimmunosorbentassay(ELISA).Results TheplasmaDD andFMlevelsweremuchhigher,whiletPAlevelwasmuchlowerinhypertensivesthanthoseof normalcontrols,exacerbating withtheseverityof thedisease.DBPwas positivelycorrelatedwithplasmaFM level(r=0.374,P0.001).In patientswithleft ventricularhypertrophy,leftventriuclarenlargementandleftatrialenlargement,higherlevelsof DD,FM andtPAwere detected.Nifedipinetreatmentproducedsignificantreductionin plasmaDD andFM levels alongwiththeincreasein tPA level [DD:(40.7±23.5)mg/dlvs(23.8±16.5)mg/dl;FM:(7.0±1.6)ng/μl vs(4.8±1.5)ng/μl;tPA:(0.31±0.14)ng/mlvs(0.41±0.05)ng/ml,P0.001].Conclusion EnahncedcoagulativeactivityandloweredfibrinolyticactivitycharacterizeEHpatients andnifedipinemaycorrect thisdisorder.