AB0630 CLINICAL CHARACTERISTICS ANALYSIS AND LITERATURE REVIEW OF 55 CASES OF PANNICULITIS

Background: Panniculitis is a heterogeneous inflammatory disease involving subcutaneous fat. It can be divided into different subtypes according to the clinical characteristics and pathological changes of the disease. Because the cause of panniculitis is unclear, clinical manifestations are diverse, lack of specificity, early diagnosis is difficult, and misdiagnosis and missed diagnosis are prone to occur. Objectives: To improve the clinical understanding of the disease by retrospective analysis of 55 cases of patients with panniculitis. Methods: The hospitalized patients with panniculitis were collected from December2011 to October 2018 in the Shanxi Dayi Hospital affiliated to Shanxi Medical University. The demographics, clinical manifestations, auxiliary examinations and treatments were analyzed and summarized. Results: The proportion of males and females in the 55 patients was 1:2.23, with an average of 53.3 years (18-82 years). A total of 52 cases of nodular panniculitis (including 14 cases of mesenteric involvement) and 3 cases of special type of panniculitis were collected. Patients with nodular panniculitis often find subcutaneous nodules or masses. According to the affected parts, they are divided into skin type and system type. Among them, 10 cases are skin type and 42 cases are system type. The most common parts is mesenteric and kidney involvement. 9 of 55 patients was combined with tumor. Patients with mesenteric panniculitis mainly present abdominal pain and bloating, which are mainly diagnosed according to CT. Patients with systemic panniculitis can be significantly relieved after treatment with hormones and immunosuppressive agents. Conclusion: Panniculitis is an inflammatory disease of unknown etiology. It is common in middle-aged and elderly people. It has various clinical manifestations and lacks specificity. The diagnosis is mainly based on pathological results. It is easy to be combined with tumors. When subcutaneous nodules are found, pathological examination should be improved in time in order to avoid misdiagnosis. References [1] Daskalogiannaki M1, Voloudaki a, Prassopoulos P, et al.CT evaluation of mesenteric panniculitis: prevalence and associated diseases[J].AJR am J Roentgenol. 2000Feb;174(2):427-31.doi:10.2214/ajr.174.2.1740427. [2] Chinese Medical association Rheumatology Branch. Guidelines for the diagnosis and treatment of nodular panniculitis (draft). Chinese Journal of Rheumatology,2004, 8 (4): 253-255. Doi:10.3760/j:issn:1007-7480.2004.04.017. [3] Hongyan Liu, Juan Meng, Yuewu LIu, et al. Report of seven cases of lipitis in the pancreatitis and literature review [J]. Chinese Journal of Rheumatology, 2018, 22 (9): 627-630, after insertion 3.doi: 10.3760/cma. j.issn.1007-7480.2018.09.010. [4] Litong Wang, Yujian Cai. Multi-slice spiral CT imaging features of mesenteric panniculitis[J].Chinese Journal of Digestive Surgery,2017,16(6):624-628.doi:10.3760/cma.j.issn.1673-9752.2017. 06.018. [5] Gaobiao Zhou, ZhiyongYao, Bin Sun, et al.A case report of nodular panniculitis with lung and kidney damage as the first manifestation[J].Chinese Journal of Urology,2007,28(4):283.doi: 10.3760/j:issn:1000-6702.2007.04.028. [6] Moraes aJ, Soares PM, Zapata aL, et al.Panniculitis in childhood and adolescence[J].Pediatr int. 2006Feb;48(1):48-53. doi:10.1111/j.1442-200X.2006.02169.x [7] Jinfang Gao, Zhang Liyun Zhang, Xiaofeng Li, et al. Clinical characteristics and prognosis of 25 cases of nodular panniculitis[J].Chinese Remedies & Clinics, 2013,13(8):1093—1095. DOI: 10.11655/zgywylc2013.08.060. [8] Lopez-Lerma I, Penate Y, Gallardo F, et al.Subcutaneous panniculitis-like T-cell lymphoma: Clinical features, therapeutic approach, and outcome in a case series of 16 patients[J].J am acad Dermatol. 2018Nov;79(5):892-898. doi: 10.1016/j.jaad.2018.05.1243. Disclosure of interests: None declared