Mast cell proliferation and activation in disease processes

: Mast cells are well known as pivotal players in the development of allergic diseases. Their most acknowledged mechanism of activation is cross-bridging of the IgE receptor. However, in recent years, the complex structure and function of these cells have been recognized as well as their diverse pathophysiological contributions. This review attempts to delineate the various ways in which mast cell proliferation and activation are involved in disease processes.