564. A Five-Year Evolutionary Study of the Minimum Inhibitory Concentrations of Methicillin-resistant Staphylococcus aureus to Mupirocin, Chlorhexidine, and Octenidine in a Singaporean Tertiary Institution

Background Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of healthcare-associated infection. Eradication of MRSA carriage reduces clinical infection and prevents transmission. In Singapore General Hospital, a series of hospital-wide measures were instituted over three years (Figure 1) to reduce mupirocin (MUP) resistance, and to decrease the bioburden of MRSA colonization amongst inpatients using octenidine (OCT)-based products.