Dysbiosis of gut microbiota was closely associated with psoriasis
2018
Psoriasis is an autoimmune disease and gut microbiota participate
in the establishment of intestinal immunity. This study was performed
to identify the fecal microbial composition of psoriasis patients,
and investigated the influence of subgroup (type and severity) on
the fecal microbial composition, and to define the key microbiota
in the pathogenesis of psoriasis. Fecal samples from 35 psoriasis
patients and 27 healthy controls were sequenced by 16S rRNA and then
analyzed by informatics methods. We found that the microbiota of the
psoriasis group differed from that of the heathy group. The relative
abundances of Firmicutes and Bacteroidetes were inverted at the phylum
level, and 16 kinds of phylotype at the genus level were found with
significant difference. No microbial diversity and composition alteration
were observed among the four types of psoriasis. The microbiota of
psoriasis patients in the severe state differs from those of psoriasis
patients with more mild conditions and also the healthy controls.
The veillonella in fecal microbiota showed a positive
relationship with h-CRP in blood. This research proved that psoriasis
patients have a significant disturbed microbiota profiles. Further
study of psoriasis based on microbiota may provide novel insights
into the pathogenesis of psoriasis and more evidence for the prevention
and treatment of psoriasis.
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