Abstract 11678: Early Strain Echocardiography May Exclude Significant Coronary Artery Stenosis in Suspected Non-ST-Elevation Acute Coronary Syndrome

Background: Many patients with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS) have no significant coronary artery disease. Current diagnostic approach with repeated ECG and cardiac biomarkers requires observation for at least 6-12 hours. The aim of this study was to investigate whether global strain by echocardiography measured at admission may exclude significant coronary artery stenosis in patients presenting with inconclusive ECG and normal cardiac biomarkers. Methods: Patients without known coronary artery disease presenting with suspected NSTE-ACS were enrolled consecutively. 12-lead ECG, Troponin t assay and echocardiography was performed on admission and patients underwent coronary angiography after 27±18 hours. Conclusive ECG was defined as >1 mm ST-segment change in any lead. Troponin t >0.03 µg/L was considered abnormal and >50 % stenosis of any coronary artery was considered significant. Echocardiography was analyzed by a single observer blinded to patient data. Global peak systo...