Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

Hadi Molanaei,Abdul Rashid Qureshi,Olof Heimbürger,Bengt Lindholm,Ulf Diczfalusy,Björn Anderstam,Leif Bertilsson,Peter Stenvinkel

Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

2018

Hadi Molanaei
Abdul Rashid Qureshi
Olof Heimbürger
Bengt Lindholm
Ulf Diczfalusy
Björn Anderstam
Leif Bertilsson
Peter Stenvinkel

Background Recent studies indicate that inflammation may also affect CYP3A4 activity. Associations of CYP3A4-mediated metabolism of quinine, with inflammatory biomarkers were investigated in patients undergoing maintenance hemodialysis (HD).

Keywords:

Inflammation
Hemodialysis
Quinine
Diabetes mellitus
CYP3A4
Pharmacology
Biomarker (medicine)
Drug metabolism
Medicine
maintenance hemodialysis
in patient

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