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topical application of yolk lecithin liposomes reinforces skin barrier function against chemical agents such as psoriasis inducing imq and alleviates disease phenotype
2018
1. Abstract 1.1. Background: Compromised skin
barrier is a major driver of skin diseases such as psoriasis. We hypothesized
that Yolk Lecithin Liposomes (YLLs) being water soluble bi-lipid membrane
vesicles rich in skin barrier lipid and their precursors would be efficient in enhancing skin barrier. We tested
this hypothesis by applying YLLs topically to
Imiquimod (IMQ)-induced mouse model of psoriasis for evidence of skin
barrier protection against IMQ and alleviation of the disease phenotype. 1.2. Materials and Methods: 100 nm
YLLs were first tested for effects on human MSC proliferation, collagen
production in human dermal fibroblasts and penetration into human skin. They were then tested for efficacy
in enhancing skin barrier against IMQ infiltration in a psoriasis mouse model. After
6 daily topical applications of IMQ and then a cream with YLLs or cream alone,
barrier efficacy was assessed by the severity of psoriatic symptoms and
cytokine induction in the skin lesion. 1.3. Results: YLLs are
non-toxic, and can enhance cell proliferation and collagen production. They
readily permeated the stratum corneum. They alleviated psoriatic skin pathology
and reduced IL-23 and TNF- a in
the skin lesion of an IMQ-induced psoriasis mouse model. 1.4. Conclusion: YLLs are effective
in enhancing the skin barrier as evidenced by the alleviation of IMQ-induced
psoriasis. 2. Keywords: Liposome;
Psoriasis; Skin barrier; Yolk lecithin
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