BPC 157 antagonized the general anaesthetic potency of thiopental and reduced prolongation of anaesthesia induced by L-NAME/thiopental combination.

Mladen Zemba,Andrea Zemba Cilic,Igor Balenovic,Matija Cilic,Bozo Radic,Jelena Šuran,Domagoj Drmic,Antonio Kokot,Vasilije Stambolija,Tamara Murselovic,Jadranka Katancic Holjevac,Sandra Uzun,Viktor Djuzel,Josipa Vlainić,Sven Seiwerth,Predrag Sikiric

BPC 157 antagonized the general anaesthetic potency of thiopental and reduced prolongation of anaesthesia induced by L-NAME/thiopental combination.

2015

Mladen Zemba
Andrea Zemba Cilic
Igor Balenovic
Matija Cilic
Bozo Radic
Jelena Šuran
Domagoj Drmic
Antonio Kokot
Vasilije Stambolija
Tamara Murselovic
Jadranka Katancic Holjevac
Sandra Uzun
Viktor Djuzel
Josipa Vlainić
Sven Seiwerth
Predrag Sikiric

Aim We hypothesized that certain effects of the general anaesthetic thiopental are dependent on NO-related mechanisms, which were consequently counteracted by stable gastric pentadecapeptide BPC 157.

Keywords:

Prolongation
Diabetes mellitus
Arginine
Anti-ulcer Agent
Potency
General anaesthetic
Pharmacology
Medicine
Anesthesia
Drug synergism
NG-Nitroarginine Methyl Ester

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