Abstract W MP117: Intracarebral Hemorrhage Volume Growth and Lipid Lowering Agent use: Pooled Analysis of Interact Studies

Background and rationale: Despite several recent reviews of randomised trials, there remains controversy of the risks of intracerebral hemorrhage (ICH) associated with regular use of statins for prevention of cardiovascular disease, particular in populations with a high risk of ICH. We aimed to determine the risk of poor outcome and hematoma growth from use of lipid lowering agents among participants of the INTERACT substudies. Design: Pooled analyses of INTERACT 1 and 2, international, multicenter, prospective, open, blinded endpoint, randomized controlled trials, of patients with ICH (<6 hr) and elevated systolic BP (SBP 150-180 mmHg). Associations between lipid lowering treatment and clinical outcomes (n=3184) were estimated in analyses of co-variance. Digital images from CT substudies participants (n=1310) underwent blinded central analyses comparing measurements from standardized baseline and 24 hrs CTs. Associations between lipid lowering treatment and hematoma volume growth from baseline to 24 hrs ...