Effect of argentum colloid on Hemagglutinating property of Newcastle disease virus (NDV

Newcastle disease virus (NDV) is a non-segmented, single-stranded, negative sense RNA virus belonging to order Mononegavirales, family Paramyxoviridae, subfamily Paramyxovirinae, genus Avulavirus. It has the capacity to agglutinate the red blood cell (RBC) of mammalian and other birds due to presence of HN protein on its surface. In current study four different concentrations of silver colloid were used in the form of three treatments- pre, co and post and their effect on HA property of NDV was observed. It was found that silver Nanoparticles show a concentration dependent inhibition on HA activity of Newcastle disease virus. The decrease in the log HA titer was significant in case of co-treatment and post-treatment at all concentrations of AgNPs except 0.84 µg/ ml and no significant difference was seen when the two treatments were compared with each other.