Endogenous glucose release in hyperdynamic porcine endotoxin shock: NG-monomethyl-L-arginine (L-NMMA) versus noradrenaline

Inhibition of nitric oxide (NO) synthesis is currently investigated for the treatment of hypotension associated with septic shock. Since both endotoxin (ETX) and NO have been reported to influence gluconeogenesis we compared the effects of standard vasopressor therapy with noradrenaline (NOR) to L-NMMA on endogenous glucose release during long-term ETX induced shock.