Is migraine a neuronal channelopothy

: Over the past 15 years an increasing awareness of the role of mutant ion channels in the pathogenesis of episodic neurological disorders has emerged. Molecular characteristic of genetic channelopathies, that are rare and monogenic, contributed to a better understanding of abnormalities in common episodic diseases such as migraine and epilepsy. Familial hemiplegic migraine, a rare autosomal dominant subtype of migraine with aura, is the first evidence implicating migraine as a neuronal channelopathy.