Anti-inflammatory analgesics and drugs used in gout

Publisher Summary This chapter discusses several anti-inflammatory analgesics and drugs used in gout. The use of non-steroidal anti-inflammatory drugs (NSAID) is associated with a three-fold increased risk of upper gastrointestinal bleeding and perforation compared with untreated controls Analgesic nephropathy is a chronic renal disease characterized by renal papillary necrosis and chronic interstitial nephritis caused by chronic abuse of compound analgesics containing aspirin or antipyrine combined with phenacetin, paracetamol, caffeine, and codeine. Flank pain associated with reversible renal failure is a well-known adverse effect associated with suprofen. Potential dangers of long-term use of NSAIDs in osteoarthritis have been questioned because of a suspected deleterious effect on the evolution of the disease. The capacity of indomethacin to have deleterious effects on renal function in patients with decompensated cirrhosis is further complicated by ascites.