The protective effects of lidocaine and furosemide on the pyramidal cell in hippocampal CA_3area after stress stimulation in the castrated rat

The present study showed that the pyramidal cells of CA 3 area were more sensitive to the stress in castrated rats than that in the normal rats. It was also discovered that lidocaine and/or furosemide applied to the ventricle produced a protective effect on the pyramidal cell of CA 3 area in castrated stress rats. Dark Neuron staining indicated that stress could injure not only the neurons of hippocampal CA 3 area, but also injures those of other brain areas including the CA 4 area, cerebellum and septum area etc. These results suggested that lidocaine and furosemide might play an important role in preventing from neuronal injury in the hippocampal CA 3 area elicited by stress, and this effect might result from depression of the Na + Ca 2+ reverse transportation and the Na + K + 2Cl cotransportation. \[