Abstract 20118: Current Smoking and Renal Dysfunction are Important Prognostic Factors following Successful De-novo Chronic Total Occlusion Intervention: 3-year Outcome Analysis

Background: Procedural success rates of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) has dramatically improved in recent years due to development of new devices and techniques. However, limited data are available for long-term prognostic clinical factors following successful PCI for de-novo coronary CTO lesions. We evaluated important prognostic factors in patients (pts) underwent successful de-novo CTO PCI during 3-year clinical follow up. Method: Between March 2004 and December 2012 total 266 consecutive pts who underwent successful PCI for de-novo coronary CTO lesions were enrolled; among them, 195 pts (73.3%) were male. The mean age was 62.2±23 years. Multi-vessel CTO and failed CTO PCI pts were excluded. Renal dysfunction was defined as eGFR 2 . Major adverse cardiovascular events (MACE) was defined as a composite of death, myocardial infarction (MI), target CTO lesion revascularization (TLR) and target CTO vessel revascularization (TVR). Independent predictors for MACE were evaluated up to 3 years. Results: At 3-year follow-up, current smoking (HR 3.567; 95% CI, 1.352-9.409; p = 0.010), and renal dysfunction (HR 5.297; 95% CI, 1.130-24.821; p = 0.034) were independent predictors of MACE following successful de-novo CTO PCI (Table). Conclusion: Current smoking and renal dysfunction are important prognostic factors following successful de-novo CTO PCI at 3 years.