Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

Palmer Rh,Jukka Mäenpää,Alexandra Jauhiainen,Bengt Larsson,John Mo,Muir Russell,James Root,Susanne Prothon,Ligia Chialda,Pablo Forte,Torbjörn Egelrud,Kristina Stenvall,Philip Gardiner

Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

2018

Palmer Rh
Jukka Mäenpää
Alexandra Jauhiainen
Bengt Larsson
John Mo
Muir Russell
James Root
Susanne Prothon
Ligia Chialda
Pablo Forte
Torbjörn Egelrud
Kristina Stenvall
Philip Gardiner

Neutrophil serine proteases (NSPs), such as neutrophil elastase (NE), are activated by dipeptidyl peptidase 1 (DPP1) during neutrophil maturation. High NSP levels can be detrimental, particularly i ...

Keywords:

Diabetes mellitus
Neutrophil elastase
Dipeptidyl peptidase
Medicine
Neutrophil maturation
Pharmacology
healthy subjects
Proteases
Serine
Anesthesia

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