Effects of methylprednisolone on collagen biosynthesis in healing acute myocardial infarction

Abstract The use of methylprednisolone to limit the myocardial damage of acute myocardial infarction (AMI) may retard the progression of infarct healing and cause scar thinning. 1,2 It is unknown whether biochemical alterations in scar formation also accompany defective healing. To better understand the nature of altered healing in the evaluation of potential therapeutic interventions, we investigated experimentally whether alterations in collagen content, major genetic subtypes and cross-links occur late during healing, following early treatment with methylprednisolone after AMI.