Effects of Severe Protein Restriction with Ketoanalogues in Advanced Renal Failure

Objective: To compare a severe protein restriction diet supplemented with ketoanalogues to a moderate protein restriction diet in order to limit glomerular filtration rate (GFR) decrease in an advanced renal insufficiency stage.Design: Prospective randomised study conducted to compare a severe protein restriction diet (0.30 g/kg/day) supplemented with a preparation of ketoanalogues, hydroxyanalogues of aminoacids and aminoacids (Group A) to a moderate protein restriction diet (0.65 g/kg/day) (Group B).Patients: 50 uremic patients included (25 in each group) with GFR is <20 mL/min/1.73m2.Results: There were no statistically significant differences between the two dietary regimens for the renal survival. But uremia decreased significantly in Group A (22.7±5.2 to 18.5±6.7 mmol/L) and increased in Group B (26.8±9.0 to 34.9±9.9 mmol/L). Calcemia increased in Group A from 2.28±0.18 to 2.42±0.17 mmol/L, p<0.01 with a stable phosphoremia while calcemia decreased in Group B (2.33±0.18 to 2.25±0.17 mmol/L, p<0.05)....