Impact of Shenfu Qiangxin Pills on Cardiac Function, Brain Natriuretic Peptide and Inflammatory Factor Levels in Patients with Chronic Heart Failure

Objective:To investigate the impact of Shenfu Qiangxin pills on cardiac function,brain natriuretic peptide and inflammatory factor levels on patients with chronic heart failure(CHF).Method: Seventy-six cases of CHF were equally divided into treatment group(39 cases) and control group(37 cases).The control group was given conventional western treatment,the treatment group was used Shenfu Qiangxin pills 6 g,tid for 8 weeks on the basis of the control group.Cardiac function,left ventricular function,traditional Chinese medicine(TCM) syndrome score,N-terminus of the original brain natriuretic peptide(NT-proBNP),C-reactive protein(CRP),tumor necrosis factor(TNF-α)and interleukin-6(IL-6) in the two groups were observed before and after the intervention.Result: The treatment group was better than the control group on the aspects of decreasing left ventricular end diastolic diameter(LVEDD) and increasing ventricular ejection fraction(LVEF)(P0.01).The TCM syndrome scores,plasma NT-proBNP level,plasma CRP,TNF-α and IL-6 levels in the treatment group were lower than those in the control group(P0.01).Conclusion: Shenfu Qiangxin pills can significantly improve cardiac function in patients with CHF,reduce TCM syndrome score and reduce the level of plasma NT-proBNP.Its mechanism may be related to the inhibition of inflammatory cytokines to reduce the inflammatory response.