p27 in FLT3-driven acute myeloid leukemia: many roads lead to ruin

Acute myeloid leukemia (AML) is an aggressive, genetically diverse hematopoietic stem cell (HSC) malignancy with a generally poor prognosis: most patients die from the disease or from successive but futile rounds of chemotherapy. The FMS-like tyrosine kinase 3 ( FLT3 ) gene is frequently altered in