Experimental Study on Preparation Security of Matrine Glucose Injection

Objection: To observe the preparation security of Matrine Glucose Injection (MGI). Method: According to the Examining and Approving Method for New Drug promulgated by the State Supervising and Administering Bureau of Drugs, the rabbit erythrocytes were collected for detecting the haemolytic effects of MGI. The whole body hypersensitivity in Guinea pigs was induced by intravenous injection of MGI through tibial vein,and its stimulation to blood vessel was conducted by intravenously dripping MGI through the vein at the border of rabbit ear, once a day, for 7 days. Result: MGI had no haemolytic effects on rabbit erythrocytes in vitro, and it could not induce the whole body hypersensitivity in guinea pigs, and its stimulation to the vein at the border of rabbit ear could not be found. Conclusion: MGI is a secure preparation for intravenous injection.