An evaluation of D-xylose absorption measurements in children suspected of having small intestinal disease

EN'I'IqUSIAM for the assessment of D-xylose absorption in patients with gastroenterologic disorders has waxed and waned as various clinical techniques have been developed and subsequently evaluated. A recent study using a relatively large dose of xylose, based on the patient's body surface area, found a close relationship between proximal intestinal mucosal damage and blood concentrations measured one hour later.' We describe a prospective clinical assessment of this same technique in a group of children suspected of having gastroenterologic disease. Our data suggest that the test is of limited value in discriminating between patients with celiac disease, those with less specific mucosal damage, and those with normal small intestinal mucosal structure. MATERIAL AND METHODS