Abstract 12341: Combined Assessment of Urinary Liver-Type Fatty-Acid Binding Protein and Serum N-Terminal Pro-B-Type Natriuretic Peptide Levels Improves Prediction of Acute Kidney Injury in Patients Hospitalized to Coronary Care Units

Background: Urinary concentration of liver-type fatty-acid binding protein (L-FABP) reflects tubulointerstitial injury. We prospectively investigated the predictive value of urinary L-FABP, both independently and in combination with serum N-terminal pro-B-type natriuretic peptide (NT-proBNP), for AKI which develops after admission to coronary care units (CCUs). Methods: We studied 1565 patients (mean age of 68 yrs) who admitted to CCUs. Baseline urinary L-FABP and serum NT-proBNP levels were measured on admission. Among these patients, heart failure was present in 39%, and acute coronary syndrome in 48%. AKI was diagnosed and classified according to the KDIGO criteria. Results: Urinary L-FABP levels correlated with serum NT-proBNP levels (r = 0.29, p < 0.0001). AKI developed in 289 (18.5%) patients, and AKI stage 2 or 3 in 63 patients. Patients with AKI were older (median, 71 vs. 68 yrs, p < 0.0001), had a higher prevalence of heart failure (54 vs. 36%, p < 0.0001), higher serum levels of NT-proBNP (3168 ...