Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures

Objective Available evidence points to a role of cytochrome P450 (Cyp) drug biotransformation enzymes in central nervous system (CNS) diseases, including epilepsy. Deviations in drug pharmacokinetic profiles may impact therapeutic outcomes. Here, we ask whether spontaneous recurrent seizure (SRS) activity is sufficient to modulate the expression of major Cyp enzymes in the liver and brain.