Advances of necroptosis in acute pancreatitis

Acinar cell death is the key event in the process of acute pancreatitis,the main mode of acinar cell death included apoptosis and necrosis.So far,the signaling pathways of apoptosis have been studied more thoroughly.In contrast,another cell death mechanism-necrosis is poorly understood.Recently,RIP1 and RIP3 of the RIP kinase family have been certified to participate and regulate the process of necroptosis.So the further identification of related proteins and the exact molecular mechanism will have profound impact on the clarification of acute pancreatitis as well as the introduce of new therapeutic targets.