Intraocular light scatter in patients on topical intraocular pressure–lowering medication

Purpose:To quantify ocular light scattering in patients under treatment with intraocular pressure–lowering eye-drops.Methods:In this prospective, observational, cross-sectional case series study, 160 eyes of 160 patients with primary open angle glaucoma or primary ocular hypertension were consecutively recruited from our Glaucoma Department over 7 months. In total, 46 eyes of 46 healthy volunteers matched for age and sex served as the control group. The variables recorded in a single visit were as follows: drug and number of drops per day, treatment duration, OXFORD corneal staining grade, lower tear meniscus height as measured by spectral domain optical coherence tomography, ocular redness and non-invasive tear breakup time measured with the Oculus Keratograph 5M, ocular surface disease index questionnaire score and objective scatter index through a double-pass technique (Optical Analysis System II).Results:Objective scatter index was higher in the patient group (3.1, interquartile range = 1.8–5.47) than...