Changes in Peripheral Hemodynamics and Clinical Symptoms in Patients With Arterial Hypertension and Abdominal Obesity Under the Influence of Treatment, Depending on Genes' Polymorphism

In 110 patients with essential arterial hypertension (EAH) and overweight or abdominal obesity (AO) analyzed changes of peripheral hemodynamics and clinical signs under the influence of treatment, depending on genes’ polymorphism of the Angiotensin-converting enzyme (ACE, I/D) and the Peroxisome proliferator-activated receptor gamma-2 (PPAR-2, Pro12Ala). Under the combined treatment the "target" office blood pressure (BP) was achieved in 72.8 % subjects, the "adequate" reduction of BP – in 82.6 % patients. Depending on the EAH severity: "target" BP achieved in 100% patients with EAH I stage vs 76.2 % in person with EAH II stage (p=0.019) and 53.1 % – with EAH III stage (p=0.002). "Target" average daily BP24, daily BPd and nighttime BPn were achieved in 70.0 % patients (prevail those with EAH I-II stages by 47.1 % and 21.2 % (p=0.049), respectively, in I-allele carriers of ACE gene – by 17,9% (p=0.048) and Ala-allele carriers of PPAR-2 gene by 38.9 % (p=0.036).