CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis.

Xian-Ming Xia,Fangyu Wang,Wen-An Xu,Zhen-Kai Wang,Jiong Liu,Youke Lu,Xinxin Jin,Heng Lu,Yunzhu Shen

CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis.

2010

Xian-Ming Xia
Fangyu Wang
Wen-An Xu
Zhen-Kai Wang
Jiong Liu
Youke Lu
Xinxin Jin
Heng Lu
Yunzhu Shen

CONCLUSION: The CXCR4 antagonist AMD3100 exerts therapeutic effects on experimental colitis by inhibiting colonic inflammation and enhancing epithelial barrier integrity.

Keywords:

Inflammation
Colitis
General surgery
Therapeutic effect
Apoptosis
CXCR4 antagonist
Immunology
Inflammation mediators
Pharmacology
Diabetes mellitus
Medicine
dextran sulfate
experimental colitis
epithelial barrier

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