EVALUATION OF THE ASSOCIATION OF THE F2R IVS-14A/T PAR-1 POLYMORPHISM WITH STENT THROMBOSIS AND SUBSEQUENT CARDIOVASCULAR EVENTS IN A COHORT OF CORONARY ARTERY DISEASE PATIENTS

The protease-activated receptor 1 (PAR1), encoded by F2R, is found on the surfaces of platelets and vascular endothelial cells. Thrombin potently activates PAR1 (and PAR4) on human platelets. Phase III studies of PAR-1 antagonists administered to patients managed with dual anti-platelet therapy have