Procedimentos Operativos Normalizados para pesquisa de informação clínica sobre reações adversas no contexto da infeção VIH/SIDA

Information related to adverse effects of antiretroviral therapy can determine non-compliance and future therapeutic options. Evidence based practice includes a focalized clinical question to obtain the better information assessed by the parameters sensitivity and specificity. The main purpose of the work is the optimization of a systematic methodology of research clinical information about adverse effects of antiretroviral therapy, in MEDLINE database, with their identification in the literature and the construction of different search strategies to subsequent comparison of sensitivity and specificity values. A generic search strategy developed to find information related to drug iatrogenicity was considered as a reference to the development of search studied strategies.  The results show the known adverse effects of antiretroviral agents that are mainly found in case reports. As the first work that approaches two different concepts simultaneously, adverse effects of antiretro-viral therapy and evidence based medicine approach to search literature, it shows and reinforces the real need for more available information to a better assessment of its quality.