Maternal 75g OGTT glucose levels as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus

Objective: Our goal was to investigate the effects of glucose levels from 75-g oral glucose tolerance test (OGTT) on large for-gestational-age (LGA) newborns in women with gestational diabetes mellitus (GDM). Methods: One hundred and eighteen pregnant women were prospectively screened for GDM between 24 and 28 weeks of pregnancy. Results: From 118 pregnancies, 78 (66.1%) women were with GDM, and 40 (33.9%) without GDM. There were statistically significant differences (30.7 versus 5.0%, p<0.01) between LGA newborns from GDM and control group, respectively. Gestation week of delivery and fasting glucose levels were independent predictors for LGA (Beta=0.58 and Beta=0.37 respectively, p<0.01). Areas under the receiver operator characteristic curve (AUC) were compared for the prediction of LGA (0.782 (0.685-0.861) for fasting, 0.719 (0.607-0.815) for 1-hour and 0.51 (0.392-0.626) for 2-hour OGTT plasma glucose levels). Conclusion: Fasting and 1-hour plasma glucose levels from OGTT may predict LGA babies in GDM pregnancies.