Left ventricular myocardial systolic function before and after chemotherapy in patients with acute leukemia by quantitative tissue velocity imaging

Objective The diagnostic value of two-dimensional echocardiography(2-DE) and quantitative tissue velocity imaging(QTVI) were compared in left ventricular myocardial systolic function before and after chemotherapy in patients with acute leukemia.Methods Sixteen patients in case group were confirmed by bone marrow aspiration,twenty-three normal subjects were in control group.Ejection fraction(EF) and stroke volume(SV) were measured by the method of Simpson.Peak velocity during systole(VS) was measured at the mitral annular level in three apical longitudinal views using QTVI.The parameters of left ventricular systolic function acquired by the method of Simpson and QTVI were compared.Results The myocardial systolic function had no obviously difference between control and case groups before chemotherapy.The method of Simpson had no positive results in detecting left systolic function in the study.However,VS was decreased in left ventricular lateral wall and anterior septum of mitral annulus detected by QTVI.Conclusion QTVI can evaluate the integral myocardial systolic function quantitatively and monitor the changes of myocardial function after chemotherapy.The diagnostic sensitivity of QTVI on myocardial function is higher than the Simpson method.