A Functionalized Magnetic Graphene-Based MOFs Platform as the Heterogeneous Mimic Enzyme Sensor for Glucose Detection

A facile one-step route was presented to prepared NH2-MIL-88B(Fe) and Fe3O4 modified reduced graphene oxide nanoparticles (NH2-MIL-88B(Fe)@MRGO) as mimic enzymes. The as-prepared NH2-MIL-88B(Fe)@MRGO exhibits a higher affinity for hydrogen peroxide and thus possessed a prominent peroxidase-mimic activity. Under the most favorable conditions, the hybrid nanomaterials with high catalytic velocity (2.57 × 10−7 M s−1) and affinity (Km = 0.0091 mM) for substrates of H2O2 display a great glucose detection performance in the range of 20–800 μM with a Limit of detection (LOD) of 3.16 μM (S/N = 3). Favorable mimic enzymes catalysis is achieved on NH2-MIL-88B(Fe) and Fe3O4 modified reduced graphene oxide nanoparticles (NH2-MIL-88B(Fe)@MRGO) for glucose detection.