AB1239 GENDER DIFFERENCE IN PULMONARY ARTERIAL HYPERTENSION, ASSOCIATED WITH CONNECTIVE TISSUE DISEASES

Background: Pulmonary arterial hypertension (PAH) is a progressive fatal disease with a known gender dimorphism. However, data on gender differences at patients with pulmonary arterial hypertension, associated with connective tissue diseases (PAH-CTD), currently not enough. Objectives: Therefore, this study aimed to investigate the role of gender in clinical future, hemodynamic data and survival PAH-CTD. Methods: We examined the long-term prognosis of 97 consecutive PAH-CTD patients, mean age 49 years (7 males and 90 females) diagnosed in our Institute from January 2009 to December 2018. The primary outcome was death. We used nonparametric analysis, Cox regression and the Kaplan-Meier method to assess variables obtained at baseline. All patients received PAH-specific therapy according to the current recommendations. Results: We found that male patients had differences in diagnosis duration, level of creatinine, uric acid, RAP. We did not reveal differences in age, a functional class, a risk scale, and the majority clinical, tool and hemodynamic indicators. However, there were significant differences in survival. So, in male group survival was 21 [12; 51] months, in comparison in female group 74 [48; 119] months, p Conclusion: These results indicate that female PAH-CTD patients have better long-term prognosis than male, despite lack of many distinctions. It needs to be considered at outcome assessment. Disclosure of Interests: Alexander Volkov : None declared, Natalia Yudkina: None declared, Ekaterina Nikolaeva: None declared, Evgeny Nasonov Speakers bureau: Pfizer, Inc., MSD, Novartis, AbbVie Inc., Celgen Corporation, Biocad, Janssen, UCB, Inc.