Kinetics of anti-TG2 antibodies release into organ culture supernatants in celiac disease

that could not be clearly evaluated after GFD. Ultimately, 13/17 patients that received diagnosis without DB were aged <4 years (76% with median age 1.76). Among 114 patients that performed DB only 2 resulted in normal histology (potential CD) with a score of 1 and 3. Sixty out of 137 performed HLA: 51 of them had DQ2, 5 had DQ8 and 4 had both DQ2/DQ8. Associated disease were: 4 Hashimoto Tyroiditis, 1 Alopecia, 1 IDDM, 1 IgA deficit, 1 Pervasive developmental disorder. Conclusions:After two years of use, we can say that it should be very cautious in application of the new diagnostic criteria for CD. Great accuracy needs in evaluation of symptoms, especially those gluten-dependent, more convincing in subsequent confirmation of diagnosis. Sometimes are not enough, very high Ab levels alone. In our series the majority of patients had a score <4 and those with score like or higher than 4 are usually very young. This approach canbe aid to assist in the evaluationof theweight of eachdiagnostic sign and toprotect against overdiagnosis innotwell documentedor borderline cases. Moreover, potential CD patients are rare (2/114) but this, probably results by our habit not to submit soon to DB children with Ab titer <3 times of cut-off value.