Pharmacogenetics; mini review

The extent of genetic variations found in drug metabolism genes and its contribution to inter individual variation in response to medication remains incompletely understood Pharmacogenetics is study of the role of inheritance in inter individual variation in drug response Different factors can influence the drug metabolism which in turn changes the response of drugs The topic provides the overview the role of genetic variations that can affects the drug response Cytochrome P enzyme system is super family of metabolizing enzymes responsible for metabolism of many clinically used drugs biosynthesis and degradation of many endogenous substances Metabolism is generally occurs in two phases phase I and phase II reactions CYP is mostly involved in phase I reactions The enzyme system is involved in approximately of oxidative metabolism of drugs and of overall elimination of drugs nbsp