The Effects of Oxidative Stress on Insulin Glargine Combined with Acarbose on Treatment of Primary Type 2 Diabetes Mellitus

Objective: To observe the effects of oxidative stress on insulin glargine combined with acarbose on treatment of primary type 2 diabetes mellitus.Method: 24 of primary type 2 diabetic patients and 20 healthy persons were selected to match the sex and age.Fasting blood glucose(FPG),postprandial blood glucose(PBG),total cholesterin(TC),triglyceride(TG),glycosylated hemoglobin(HbA1c),total superoxide dismutase(SOD) and malondialdehyde(MDA) of serum were detected and compared variance of these markers before and after treatment.Result: Significant differences were identified in FPG,PBG,TC,TG and HbA1c between before and after treatment(P0.05).The level of SOD in diabetic group were significantly increased after treatment(P0.05),but less than that in healthy persons(P0.05).The level of MDA in diabetic group were significantly decreased after treatment(P0.05),but higher than that in healthy persons(P0.05).Conclusion: Patients with type 2 diabetes using insulin glargine combined with acarbose could have ideal blood glucose level and decrease oxidative stress.